Axonics Sacral Neuromodulation Therapy

What is Axonics Therapy?

Axonics Therapy is an effective solution for treating symptoms of overactive bladder (including urinary urgency incontinence), bowel (fecal) incontinence, and urinary retention. This therapy is clinically proven to help people regain bladder and bowel control.

What are the Benefits of Axonics Therapy?

Axonics Therapy provides patients with a long-term treatment solution that:

• Safely delivers therapy with a miniaturized implant
• Is designed to provide therapy for at least 15 years
• Is the first MRI compatible sacral neuromodulation technology, allowing you to undergo a full-body MRI with no problems
• Is wireless! No direct contact is required and has contact-free clinician programming access
• Is the first rechargeable system with a simple remote that is easy to use for all age groups
• Clinically proven to provide symptom relief*

How Does Axonics Therapy Work?

Axonics Therapy provides gentle stimulation to the nerves that control the bladder and bowel, which can restore normal control and result in symptom improvement.

The Evaluation Step: To see if Axonics Therapy is right for you, you will undergo a short period of therapy using a temporary system. The evaluation period allows you to experience the level of symptom relief the therapy may provide before you commit to long-term therapy.

Long-term Therapy: If you and your doctor determine that Axonics Therapy is right for you, you will have an outpatient procedure where the miniaturized Axonics implant is placed just beneath the skin in the upper part of your buttock.

Who is a Good Candidate for Axonics Therapy?

It is up to you and your healthcare provider to determine if you are a good candidate for Axonics Therapy.

Axonics Therapy is an approved treatment for patients with:

• Overactive bladder (OAB) – The urgent need to urinate which may result in frequent urinary and/or incontinence (leakage) episodes
• Urinary urgency frequency – the need to urinate 8 or more times a day
• Urinary urgency incontinence (UUI) – the urgent need to urinate or trouble holding urine before making it to the restroom
• Fecal (bowel) incontinence – sudden urges to pass stool and experience leakage of stool before making it to the restroom
• Nonobstructive urinary retention (UR) – the inability to empty the bladder which results in symptoms of frequent urination or trouble urinating

Axonics Therapy is indicated for patients who have failed conservative treatments, such as lifestyle changes, physical therapy, or medications.

Axonics Therapy Is Not Appropriate For:

• Stress incontinence
• Treating urinary symptoms caused by mechanical obstructions, such as benign prostatic hypertrophy, cancer, or urethral stricture
• Patients who have not demonstrated an appropriate response to an external trial
• Patient with limited cognitive function, which may make it difficult to manage their therapy
• Pregnant women, the unborn fetus, and during delivery
• Pediatric patients (under the age of 18 years for fecal incontinence and under the age of 16 years for OAB and urinary retention)
• Patients with neurological disease origins, such as multiple sclerosis or diabetes

Clinically Proven. Patient Approved.

Backed by clinical studies, Axonics Therapy is clinically proven to regain bladder and bowel control and deliver clinically meaningful improvement in quality of life. In a clinical study of patients with urinary urgency incontinence (after 6 months of therapy),

• 93% of patients were satisfied with their therapy*
• 90% of patients experienced a ≥50% reduction in UUI symptoms*
• <2% of patients reported discomfort at the implant site

* McCrery R, et al. Treatment of urinary urgency incontinence using a rechargeable SNM system: 6-month results of the ARTISAN-SNM study. J Urol. E-publication ahead of print July 26, 2019.